Health
cmRNAbone

Leading the Future of Bone Regeneration

Leading the Future of Bone Regeneration

At a Glance

  • Custom and patient-specific therapies using natural processes
  • Unlocking the potential of chemically modified RNA for tissue regeneration
  • Paradigm shift in how osteoporosis and large bone defects are treated

Age has become more of a feeling than a number with an older generation that is more active than ever. This new lease on life is rewriting the playbook, but it comes with a catch: bones don’t always get the memo and conditions like osteoporosis and bone injuries are becoming more common. The silver lining however is that science is stepping up.

Through an exciting interdisciplinary approach, cmRNAbone has developed custom and patient specific therapies that stimulate bone regeneration and healing through cutting-edge technology using chemically modified RNA (cmRNA). This innovation offers society an exciting and affordable opportunity to improve patients’ quality of life allowing them to recover faster and get back to doing what they love.

A Natural Healing Process

A Natural Healing Process

Bone diseases impact millions of people worldwide every year. With bone being the most transplanted tissue after blood and bone marrow, the need for new bone substitutes is high. Normally bones heal on their own, but sometimes a bone graft is required. This means taking some bone from the hip of the patient and inserting it in the injured bone. This can lead to long-lasting and recurring fractures drastically decreasing the patient’s quality of life and putting them at greater risk of other illnesses.

Bone grafting is also limited as you cannot take all of the bone from the hip to use elsewhere. This is where cmRNAbone steps in. The newly developed therapy does not need anything from the patient. Everything can be produced right in the lab and used for regeneration and healing directly at the bone injury through natural processes allowing the patient to maintain their quality of life.

The Sponge of the Future

The Sponge of the Future

Within the backdrop of recent exciting new discoveries related to RNA therapeutic agents, cmRNAbone combined the groundbreaking fields of nanomedicine, 3D printing, bioinks, hydrogels/scaffolds and cmRNA. Through 3D printing, a small gel sponge like holder is created. The holder can be made in any shape or form to best match the injured or degenerative bone. The cmRNA is then inserted into the spongy holder and contains all of the information needed to stimulate bone regeneration and healing. The holder is then placed into, or onto, the injured or degenerative bone.

The cmRNA instructs the cells of the patient’s body to make vessels, bones and nerves in a coordinated way stimulating bone growth or regeneration using the body’s own natural healing mechanisms. The results have led to a paradigm shift in how osteoporosis and large bone defects are treated and has demonstrated the potential of RNA beyond vaccination as a tool for tissue regeneration

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Nadine Drechoux
Senior Research & Impact Manager
Portfolio Manager Society
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